tnf receptor การใช้

• Impaired shedding of the TNF receptor is one of the possible defects.
• TNF receptors which are used to deactivate TNF and blunt the immune response.
• The signalling complexes with TNF receptor-1.
• This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins.
• TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily.
• TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily.
• However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.
• The protein encoded by this gene is a member of the TNF receptor associated factor ( TRAF ) protein family.
• TRAF4 is a member of the TNF receptor associated factor ( TRAF ) family, a family of scaffold proteins.
• TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor ( TNFR ) superfamily.
• TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor ( BAFF ).
• Upon contact with their ligand, TNF receptors also form trimers, their tips fitting into the grooves formed between TNF monomers.
• TNF? itself induces demyelination of the oliodendroglial via TNF receptor 1, while chronic inflammation has been linked to demyelination of neurons.
• TNF-alpha then binds to the TNF receptors expressed on nociceptors, activating the MAPK / NF-kappa B pathways.
• The two arms of the Y are TNF receptors; the stem of the Y is a fragment of a normal human antibody.
• The protein encoded by this gene is a member of the TNF receptor ( TNFR ) associated factor ( TRAF ) protein family.
• TRAF proteins connect TNF receptors with signaling factors that lead to the activation of NF-?B and mitogen-activated protein kinases.
• It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 ( TRAF1 ).
• For example, the M-T2 protein of myxoma viruses can bind TNF preventing it from binding the TNF receptor and inducing a response.
• DR4, TRAIL-R2 and CD95 are death receptors ( members of TNF receptor superfamily ) which interact together using their intracellular death domains ( DDs ).